Research

Fluorescence lifetime micro-endoscopy for in-vivo deep brain studies

In this project, we propose the development of a new imaging modality, which would facilitate submicrometre-scale observations of fluorescence lifetime in deep brain regions of living animals. Exploiting the principles of holographic endoscopy, we will introduce the prospect of Fluorescence Lifetime Imaging Microscopy (FLIM) through hair-thin multimode fibres. The minimally invasive FLIM endoscope will offer microenvironment-sensitive imaging, ideal for probing dynamic molecular processes within deep-brain structures.

English

All Magic Comes with a Price – Investigating the Ecological Trade-offs of Biodegradable Polyesters

The transition from petroleum-based polymers to biodegradable alternatives in plastic production promises environmental benefits, yet entails complex ecological footprints. This project investigates the hypothesis that the ecological impact of substituting conventional polymers with biodegradable alternatives is characterized by a nuanced trade-off between short- and long-term effects. Specifically, the release of nanoplastics into the environment represents a critical short-term concern necessitating assessment within a broader temporal context.

English

Raman spectroscopy-based mobile detection and identification solution for chemical pollutants and biological agents

The aim of the project is to develop a complex system for detection and identification of substances of interest based on Raman spectroscopy in field conditions. The system will use existing commercially available mobile Raman instruments, which will be improved with newly developed advanced accessories to increase the sensitivity and selectivity of the analyses.

English

INFASCOPE – Integrated Field emission electron source analysis

The aim of our international project INFASCOPE is to investigate new experimental methods and measurement procedures for spatially and temporally resolved electron detection from field emission (FE) cathode arrays and FE-electron sources. To gain a comprehensive understanding of the emission characteristics of modern FE-cathodes it is necessary to understand how the individual emission sites on the cathode surface interact with each other or with the residual gas during operation in vacuum. Currently available methods do not provide sufficient observation possibilities.

English
Research
Congratulations to Dr. Kamila Hrubanová, of Institute of Scientific Instruments of the CAS (ISI CAS), for appointment as President of the Czechoslovak Microscopical Society (CSMS) as of January 1, 2025. continue
Research
Department of Magnetic Resonance, ISI CAS Královopolská 147, Brno, is organizing a seminar on 3.12.2024 where you will learn about various types of magnetic resonance measurements used in preclinical research and where a number of users will speak. continue
Research
A new special issue of Neurophotonics, entitled Complex Media in Neurophotonics, has just been published by guest editors Hana Uhlířová, Tomáš Čižmár, André Gomes and Janelle Pakan. continue

Support for "Proof-of-Concept" activities at the Institute of Scientific Instruments of the CAS, v. v. i.

The goal of the presented project is, in addition to expansion of the existing system of transfer of new R&D knowledge, strengthening research and development activities towards commercially usable outputs by accelerating the commercialization system in the Proof of Concept section in accordance with the national Industry 4.0 initiative.

English
Research
Academic startup VDI Technologies has reached a significant milestone, achieving ISO 13485 certification for activities that include developing, manufacturing, and selling medical devices for electrocardiography. The rigorous certification is a prerequisite for commercializing the new ultra-high frequency ECG (VDI UHF-ECG) technology. continue
Research
Dr. Vladislav Krzyžánek, Head of the Microscopy for Biomedicine Group at the Institute of Scientific Instruments of the CAS and President of the Czechoslovak Microscopy Society, became the first representative from Central Europe to be elected to this prestigious position. Congratulations! continue

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