Research

Utilising a hair-thin multimode optical fibre, the holographic endoscope allows minimally invasive, high-resolution in-vivo imaging at subcellular levels across any brain structure. The NEUROGATE project will significantly enhance the potential of this breakthrough technology for biomedical imaging by commercialising critical innovations in holographic endoscopy, developed through the prior ERC-PoC projects WOKEGATE and StrokeGATE.

In this project, we propose the development of a new imaging modality, which would facilitate submicrometre-scale observations of fluorescence lifetime in deep brain regions of living animals. Exploiting the principles of holographic endoscopy, we will introduce the prospect of Fluorescence Lifetime Imaging Microscopy (FLIM) through hair-thin multimode fibres. The minimally invasive FLIM endoscope will offer microenvironment-sensitive imaging, ideal for probing dynamic molecular processes within deep-brain structures.

The transition from petroleum-based polymers to biodegradable alternatives in plastic production promises environmental benefits, yet entails complex ecological footprints. This project investigates the hypothesis that the ecological impact of substituting conventional polymers with biodegradable alternatives is characterized by a nuanced trade-off between short- and long-term effects. Specifically, the release of nanoplastics into the environment represents a critical short-term concern necessitating assessment within a broader temporal context.

The aim of the project is to develop a complex system for detection and identification of substances of interest based on Raman spectroscopy in field conditions. The system will use existing commercially available mobile Raman instruments, which will be improved with newly developed advanced accessories to increase the sensitivity and selectivity of the analyses.