Most diseases including cancers, viral infections, neurodegenerative conditions, cardiovascular and musculoskeletal disorders, all originate from a molecular level disruption of the biological cell lifecycle. Each year the cost to the EU is ca. 1.9 million lives and ca. €200 billion in health care, informal care and productivity loss for cancers alone. Current live cell imaging tools can only provide a limited view of the in vivo and in vitro microenvironments where diseases originate and grow.